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Tenecteplase versus alteplase for stroke thrombolysis evaluation trial

Professor Mark Parsons, Institution: University of Melbourne

2013 Future Leader Fellowship

Years funded: 2014-2020


Associate Professor Mark Parsons has made two recent advances that could bring about a global transformation in acute stroke care. The first is the use of advanced brain imaging to identify potentially salvageable brain tissue surrounding the event – the ischaemic penumbra. The second is the recent discovery in a Phase II trial that the new generation intravenous thrombolytic (blood clot-breaking) agent, Tenecteplase, provides better outcomes clinically and in managing damage as blood flow returns to the affected area, when compared to the current standard blood clot breaker, alteplase.

Tenecteplase versus alteplase for stroke thrombolysis evaluation (TASTE), conceived and led by Associate Professor Parsons, is a large Phase III randomised trial designed to generate practice-changing evidence by applying the advanced imaging treatment selection approach used in his recent positive Phase II trial. TASTE aims to confirm the superiority of Tenecteplase over alteplase in a broader group of stroke patients who are eligible for acute thrombolytic treatment in the current time window (less than 4.5 hours after stroke onset).

TASTE will address crucial clinical and pathophysiologic questions in a much broader group of stroke patients eligible for acute thrombolytic therapy. A positive study result would be applicable to millions of people worldwide (including some 25% of the more than 30,000 Australians who present early with acute ischaemic stroke each year) and will undoubtedly directly translate into a major change in clinical practice.

This project is co-funded with National Stroke Foundation.

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